New generation vaccines such as Virus-like particles (VLPs), bacterial ghosts, Outer membrane vesicles (OMVs), and SRP technology have opened new vistas in vaccine development to curb infectious diseases in livestock. Unlike conventional vaccines, such as killed bacterial vaccines, bacterial ghosts are excellent alternatives because their antigenic components remain undenatured. VLPs act as modular vaccine platforms for several viral diseases since VLPs confer dense repeating protein arrays and conformational epitopes homogeneous to those of native viruses.