Abstract
Withanolides, a group of naturally occurring steroid lactones found in the Solanaceae family, have garnered attention for their diverse biological activities, including their potential role in plant defense against biotic stress. This article reviews current research on the mechanisms through which withanolides contribute to the plant's ability to withstand biotic stressors, such as pathogens and herbivores. The antimicrobial properties of withanolides are explored, along with their impact on herbivore feeding behavior.