Indian Veterinary Research Institute (IVRI) has made immense contributions to veterinary vaccine development in India. IVRI has made indigenous vaccines at an affordable cost, which are highly efficacious under field conditions and has reduced the disease incidence in India. Further, the veterinary indigenous vaccines developed by IVRI have also substantially reduced the import burden of overseas vaccines and have contributed immensely to the national exchequer. Moreover, IVRI has played a pivotal role in the eradication of nefarious diseases such as Rinderpest and Contagious Bovine Pleuropneumonia (CBPP).